INSTITUTE OF INFLAMMATION AND NEURODEGENERATION

Publications

 2019

Figueiredo CA, Düsedau HP, Steffen J, Gupta N, Dunay MP, Tóth GK, Reglodi D, Heimesaat MM, Dunay IR.
Immune-modulatory effects of the neuropeptide pituitary adenylate cyclase-activating polypeptide in acute Toxoplasmosis.
Front. Cell. Infect. Microbiol. (Parasite and Host) 2019, accepted.

Bereswill S, Escher U, Grunau A, Kühl AA, Dunay IR, Tamas A, Reglodi D, Heimesaat MM.
Pituitary Adenylate Cyclase-Activating Polypeptide - A Neuropeptide as Novel Treatment Option for Subacute Ileitis in Mice Harboring a Human Gut Microbiota.
Front Immunol. 2019 Mar 22;10:554. doi: 10.3389/fimmu.2019.00554. eCollection 2019.

Ivanova DL, Denton SL, Fettel KD, Sondgeroth KS., Gutierrez JM, Bangoura B, Dunay IR, Gigley JP.
Innate lymphoid cells in protection, pathology, and adaptive immunity during Apicomplexan infection.
Front Immunol. 2019 Feb 28;10:196. doi: 10.3389/fimmu.2019.00196. eCollection 2019.

Knop L, Frommer C, Stoycheva D, Deiser K, Kalinke U, Blankenstein T, Kammertöns T, Dunay IR, Schüler T.
Interferon-γ receptor signaling in dendritic cells restrains spontaneous proliferation of CD4+ T cells in chronic lymphopenic mice.
Front Immunol. 2019 Feb 7;10:140. doi: 10.3389/fimmu.2019.00140. eCollection 2019.

Düsedau HP, Klevemann J, Figueiredo CA, Biswas A, Steffen J, Kliche S, Haak S, Zagrebelsky M, Korte M, Dunay IR.
p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection induced neuroinflammation.
Glia. 2019 Jan;67(1):193-211. doi: 10.1002/glia.23553.

2018

Lang D, Schott BH, van Ham M, Morton L, Kulikovskaja L, Herrera-Molina R, Pielot R, Klawonn F, Montag D, Jänsch L, Gundelfinger ED, Smalla KH, Dunay IR.
Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition.
J Neuroinflammation. 2018 Aug 1;15(1):216. doi: 10.1186/s12974-018-1242-1.

Escher U, Giladi E, Dunay IR, Bereswill S, Gozes I, Heimesaat MM.
Anti-inflammatory Effects of the Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis.
Eur J Microbiol Immunol (Bp). 2018 May 23;8(2):34-40. doi: 10.1556/1886.2018.00006. eCollection 2018 Jun 25.

Dunay IR, Diefenbach A.
Group 1 innate lymphoid cells in Toxoplasma gondii infection.
Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12516. Review.

2017

Alvarado-Esquivel C, Rico-Almochantaf YDR, Hernández-Tinoco J, Quiñones-Canales G, Sánchez-Anguiano LF, Torres-González J, Schott B, Liesenfeld O, Dunay IR.
Toxoplasma Gondii Exposure and Neurological Disorders: An Age- and Gender-Matched Case-Control Pilot Study.
Eur J Microbiol Immunol (Bp). 2017 Nov 20;7(4):303-309. doi: 10.1556/1886.2017.00033. eCollection 2017 Dec 18.

Ahmed N, French T, Rausch S, Kühl AA, Hemminger K, Dunay IR, Steinfelder S, Hartmann S.
Toxoplasma Co-infection prevents Th2 differentiation and leads to a Helminth-specific Th1 response.
Front. Cell. Infect. Microbiol. 2017 July 26;7:341. doi: 10.3389/fcimb.2017.00341.

Biswas A, French T, Düsedau H, Müller N, Riek-Burchardt M, Dudeck A, Bank U, Schüler T, Dunay IR.
Behavior of Neutrophil Granulocytes during Toxoplasma gondii Infection in the Central Nervous System.
Front Cell Infect Microbiol. 2017 Jun 21;7:259. doi: 10.3389/fcimb.2017.00259. eCollection 2017.

Van Acker A, Gronke K, Biswas A, Martens L, Saeys Y, Filtjens J, Taveirne S, Van Ammel E, Kerre T, Matthys P, Taghon T, Vandekerckhove B, Plum J, Dunay IR, Diefenbach A, Leclercq G.
A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.
Cell Rep. 2017 May 16;19(7):1431-1443. doi: 10.1016/j.celrep.2017.04.068.

 

2016

Möhle L, Mattei D, Heimesaat MM, Bereswill S, Fischer A, Alutis M, French T, Hambardzumyan D, Matzinger P, Dunay IR*, Wolf SA* contributed equally.
Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis.
Cell Rep. 2016 May 31;15(9):1945-56. doi: 10.1016/j.celrep.2016.04.074.

Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR.
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.
Acta Neuropathol Commun. 2016 Mar 16;4:25. doi: 10.1186/s40478-016-0293-8.

2015

Arroyo-Olarte RD, Brouwers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N.
Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence.
PLoS Biol. 2015 Nov 13;13(11):e1002288. doi: 10.1371/journal.pbio.1002288.

Fu T, Znalesniak EB, Kalinski T, Möhle L, Biswas A, Salm F, Dunay IR, Hoffmann W.
TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii.
Eur J Microbiol Immunol (Bp). 2015 Sep 18;5(3):221-31. doi: 10.1556/1886.2015.00028.

Montagna GN, Biswas A, Hildner K, Matuschewski K, Dunay IR.
Batf3 deficiency proves the pivotal role of CD8α+ dendritic cells in protection induced by vaccination with attenuated Plasmodium sporozoites.
Parasite Immunol. 2015 Aug 18;37:533-43. doi: 10.1111/pim.12222.

Schumak B, Klocke K, Kuepper JM, Biswas A, Djie-Maletz A, Limmer A, van Rooijen N, Mack M, Hoerauf A, Dunay IR.
Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria.
PLoS One. 2015 Apr 17;10(4):e0124080. doi: 10.1371/journal.pone.0124080.

Biswas A, Bruder D, Wolf SA, Jeron A, Mack M, Heimesaat MM, Dunay IR.
Ly6C(high) monocytes control cerebral toxoplasmosis.
J Immunol. 2015 Apr 1;194(7):3223-35. doi: 10.4049/jimmunol.1402037.

Blanchard N, Dunay IR*, Schlüter D* contributed equally.
Persistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between the parasite, the brain and the immune system.
Parasite Immunol. 2015 Mar;37(3):150-8. doi: 10.1111/pim.12173. Review.

Parlog A, Schlüter D, Dunay IR.
Toxoplasma gondii-induced neuronal alterations.
Parasite Immunol. 2015 Mar;37(3):159-70. doi: 10.1111/pim.12157. Review.

2014

Heimesaat MM, Dunay IR, Schulze S, Fischer A, Grundmann U, Alutis M, Kühl AA, Tamas A, Toth G, Dunay MP, Göbel UB, Reglodi D, Bereswill S.
Pituitary adenylate cyclase-activating polypeptide ameliorates experimental acute ileitis and extra-intestinal sequelae.
PLoS One. 2014 Sep 19;9(9):e108389. doi: 10.1371/journal.pone.0108389.

Heimesaat MM, Dunay IR, Alutis M, Fischer A, Möhle L, Göbel UB, Kühl AA, Bereswill S.
Nucleotide-oligomerization-domain-2 affects commensal gut microbiota composition and intracerebral immunopathology in acute Toxoplasma gondii induced murine ileitis.
PLoS One. 2014 Aug 20;9(8):e105120. doi: 10.1371/journal.pone.0105120.

Bereswill S, Kühl AA, Alutis M, Fischer A, Möhle L, Struck D, Liesenfeld O, Göbel UB, Dunay IR, Heimesaat MM.
The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis.
Gut Pathog. 2014 Jun 6;6:19. doi: 10.1186/1757-4749-6-19.

Klose CS, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, Fabiunke C, Pfeifer D, Sexl V, Fonseca-Pereira D, Domingues RG, Veiga-Fernandes H, Arnold SJ, Busslinger M, Dunay IR, Tanriver Y, Diefenbach A.
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Cell. 2014 Apr 10;157(2):340-56. doi: 10.1016/j.cell.2014.03.030.

Möhle L, Parlog A, Pahnke J, Dunay IR.
Spinal cord pathology in chronic experimental Toxoplasma gondii infection.
Eur J Microbiol Immunol (Bp). 2014 Mar;4(1):65-75. doi: 10.1556/EuJMI.4.2014.1.6.

Parlog A, Harsan LA, Zagrebelsky M, Weller M, von Elverfeldt D, Mawrin C, Korte M, Dunay IR.
Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity.
Dis Model Mech. 2014 Apr;7(4):459-69. doi: 10.1242/dmm.014183.

2013

Bereswill S, Fischer A, Dunay IR, Kühl AA, Göbel UB, Liesenfeld O, Heimesaat MM.
Pro-inflammatory potential of Escherichia coli strains K12 and Nissle 1917 in a murine model of acute ileitis.
Eur J Microbiol Immunol (Bp). 2013 Jun;3(2):126-34. doi: 10.1556/EuJMI.3.2013.2.6.

2012

Karlmark KR, Tacke F, Dunay IR.
Monocytes in health and disease - Minireview.
Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):97-102. doi: 10.1556/EuJMI.2.2012.2.1. Review.

Hucke S, Floßdorf J, Grützke B, Dunay IR, Frenzel K, Jungverdorben J, Linnartz B, Mack M, Peitz M, Brüstle O, Kurts C, Klockgether T, Neumann H, Prinz M, Wiendl H, Knolle P, Klotz L.
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ.
Brain. 2012 May;135(Pt 5):1586-605. doi: 10.1093/brain/aws058.

2011

Ifergan I, Kebir H, Terouz S, Alvarez JI, Lécuyer MA, Gendron S, Bourbonnière L, Dunay IR, Bouthillier A, Moumdjian R, Fontana A, Haqqani A, Klopstein A, Prinz M, López-Vales R, Birchler T, Prat A.
Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions.
Ann Neurol. 2011 Nov;70(5):751-63. doi: 10.1002/ana.22519.

Heimesaat MM, Dunay IR, Fuchs D, Trautmann D, Fischer A, Kühl AA, Loddenkemper C, Siegmund B, Batra A, Bereswill S, Liesenfeld O.
The distinct roles of MMP-2 and MMP-9 in acute DSS colitis.
Eur J Microbiol Immunol (Bp). 2011 Dec;1(4):302-10. doi: 10.1556/EuJMI.1.2011.4.6.

Heimesaat MM, Dunay IR, Fuchs D, Trautmann D, Fischer A, Kühl AA, Loddenkemper C, Batra A, Siegmund B, Krell HW, Bereswill S, Liesenfeld O.
Selective gelatinase blockage ameliorates acute DSS colitis.
Eur J Microbiol Immunol (Bp). 2011 Sep;1(3):228-36. doi: 10.1556/EuJMI.1.2011.3.7.

Mashayekhi M, Sandau MM, Dunay IR, Frickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM.
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.
Immunity. 2011 Aug 26;35(2):249-59. doi: 10.1016/j.immuni.2011.08.008.

2010

Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD.
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.
Cell Host Microbe. 2010 Dec 16;8(6):484-95. doi: 10.1016/j.chom.2010.11.005.

 

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